Perindopril in Breast Milk and Determination of Breastfed Infant Exposure: A Prospective Observational Study
| Autor: | Catherine, Leggett, Ei Mon Phyo, Lwin, Usha, Ritchie, Yunmei, Song, Jacobus P, Gerber, Sean, Turner, William M, Hague, Michael, Stark, Richard, Upton, Sanjay, Garg |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Indoles Milk Human human plasma Infant human milk Angiotensin-Converting Enzyme Inhibitors Middle Aged clinical lactation Young Adult Breast Feeding Perindopril infant drug exposure Humans Female Prospective Studies perindoprilat LC-MS/MS circulatory and respiratory physiology Original Research |
| Zdroj: | Drug Design, Development and Therapy |
| ISSN: | 1177-8881 |
| Popis: | Objective This study aimed to quantify the amount of perindopril and its active metabolite perindoprilat present in breast milk and corresponding maternal and infant plasma concentrations. Design Prospective, longitudinal, observational. Setting Tertiary specialist paediatric and obstetric hospital in Adelaide, South Australia. Population Breastfeeding women actively treated with perindopril for hypertensive disorders postpartum. Methods Eight breast milk samples and a single plasma sample were collected from each participant over a 24 hrs period, and plasma samples were taken from eligible breastfed infants. Breast milk and plasma concentrations of perindopril and perindoprilat were analysed using a validated Liquid Chromatography tandem-Mass Spectrometry (LC-MS/MS) method. Main Outcome Measures Mean breast milk concentrations of perindopril and perindoprilat, Relative Infant Dose (RID) |
| Databáze: | OpenAIRE |
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