Ras homolog gene family H (RhoH) deficiency induces psoriasis-like chronic dermatitis by promoting T
| Autor: | Norimasa, Tamehiro, Kyoko, Nishida, Yu, Sugita, Kunihiro, Hayakawa, Hiroyo, Oda, Takeshi, Nitta, Miwa, Nakano, Akiko, Nishioka, Reiko, Yanobu-Takanashi, Motohito, Goto, Tadashi, Okamura, Reiko, Adachi, Kazunari, Kondo, Akimichi, Morita, Harumi, Suzuki |
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| Rok vydání: | 2017 |
| Předmět: |
Mice
Knockout rho GTP-Binding Proteins Mice Inbred BALB C Interleukins Ubiquitin-Protein Ligases Cell Differentiation Dermatitis Receptors Interleukin Lymphocyte Activation Repressor Proteins Disease Models Animal Mice Chronic Disease Animals Humans Psoriasis Th17 Cells Cells Cultured Transcription Factors |
| Zdroj: | The Journal of allergy and clinical immunology. 143(5) |
| ISSN: | 1097-6825 |
| Popis: | Ras homolog gene family H (RhoH) is a membrane-bound adaptor protein involved in proximal T-cell receptor signaling. Therefore RhoH plays critical roles in the differentiation of T cells; however, the function of RhoH in the effecter phase of the T-cell response has not been fully characterized.We sought to explore the role of RhoH in inflammatory immune responses and investigated the involvement of RhoH in the pathogenesis of psoriasis.We analyzed effector T-cell and systemic inflammation in wild-type and RhoH-null mice. RhoH expression in T cells in human PBMCs was quantified by using RT-PCR.RhoH deficiency in mice induced TOur results indicate that RhoH inhibits T |
| Databáze: | OpenAIRE |
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