| Autor: |
Jussi P, Posti, Laura, Valve, Saku, Ruohonen, Juha, Akkila, Mika, Scheinin, Amir, Snapir |
| Rok vydání: |
2010 |
| Předmět: |
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| Zdroj: |
European journal of pharmacology. 653(1-3) |
| ISSN: |
1879-0712 |
| Popis: |
Significant inter-individual variability exists in responses of human dorsal hand veins to activation of α-adrenoceptors. Simultaneous graded infusions of the α₁- and α₂-adrenoceptor agonists phenylephrine (3.66-8000 ng/min) and dexmedetomidine (0.0128-1000 ng/min) were given into dorsal veins of both hands and responses of 75 subjects were analyzed to assess whether a subject's sensitivity to phenylephrine (ED(50)) predicts his sensitivity to dexmedetomidine. Individual ED(50) estimates of dexmedetomidine and phenylephrine ranged between 0.06-412 and 14.2-7450 ng/min and exhibited only a weak positive relationship (r² =0.074, P=0.018). Finger temperature, body mass index, age and phenylephrine sensitivity together accounted for about 30% of dexmedetomidine ED(50) variation (r² =0.315, P0.001). The large inter-individual variability observed in the responses of dorsal hand veins to both α₁- and α₂-adrenoceptor agonists is not explained by some common factors; instead, dorsal hand vein responsivity is separately determined for both receptor mechanisms. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full Text from ScienceDirect