Serum cystatin C and microalbuminuria in the detection of vascular and renal damage in early stages
| Autor: | J M, López Gómez, B, Sacristán Enciso, M, Micó, F, Arias Meneses, F, de Sande Medel, S, Alejo |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Aged 80 and over Male Aging Hyperlipidemias Middle Aged Young Adult Cross-Sectional Studies Early Diagnosis Cardiovascular Diseases Risk Factors Creatinine Chronic Disease Hypertension Diabetes Mellitus Albuminuria Humans Urea Cystatin A Female Kidney Diseases Biomarkers Aged Glomerular Filtration Rate |
| Zdroj: | Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia. 31(5) |
| ISSN: | 1989-2284 |
| Popis: | The aim of this study was to assess serum cystatin C and urinary albumin in the early detection of impairment in cardiovascular and renal function. MATERIAL ANS METHODS: Cystatin C was quantified in sera from healthy people, moreover, cystatin C was quantified in a group of patients diagnosed with chronic kidney disease for predicting a measured glomerular filtration rate60 ml/min/1.73 m2. Finally serum cystatin C and microalbuminuria were measured in patients with increasing of risk of impairment in cardiovascular and renal function (hypertension, diabetes and hyperlipidemia).When the serum cystatin C was quantified in a group of risk, we observe as when being increased the cystatin C, the values of the glomerular filtration rate decreased (p0.05), the cystatin values C were increased when increasing the age of the patients (p0.05) and cystatin C values higher than 0.95 mg/l were not observed in patient smaller than 50 years old. In the group of risk, serum cystatin C was high regarding to the values obtained in healthy people in 27.6%, microalbuminuria in the 20.3% and both parameters were high in the 14.4% of patients with a glomerular filtration rate90 ml/min/1.73 m2, while in patients with a glomerular filtration rate 60-90 ml/min/1.73 m2, cystatin C was high in the 51.7% and the microalbuminuria only in the 6.4%.Determinations of serum cystatin C associated to the quantification of urinary albumin in patients with cardiovascular risk can optimize the early detection of vascular and renal damage. Cystatin C can show vascular and renal damage in patients without urinary albumin. |
| Databáze: | OpenAIRE |
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