| Autor: |
Azhar Hatif, Al-Kuraishi, Hatham Ibraheem, Khalil, Huda Hamed, Hasan, Hayder Mutter, Al-Kuraishy |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
JPMA. The Journal of the Pakistan Medical Association. 71(12) |
| ISSN: |
0030-9982 |
| Popis: |
To investigate melatonin serum level and inflammatory biomarkers in acute toxoplasmosis in pregnant women with recurrent abortions.The case-control study was conducted at the Department of Parasitology, together with the Department of Obstetrics, Al-Yarmouk teaching hospital, Baghdad Iraq, from September 2018 until February 2019. Included were 60 pregnant women in first trimester with acute toxoplasmosis (n=28) or without toxoplasmosis (n=32) and with the history of recurrent abortions with a control group of healthy pregnant women (n=25). Melatonin and interleukins (IL-10, 1L-12) serum levels were evaluated in all groups. The data analysis was done by using SPSS 20.The mean serum melatonin level was lower in the pregnant women with acute toxoplasmosis (69.57±17.37 pg/ml) as compared to the pregnant women without acute toxoplasmosis (77.25±24.35 pg/ml), but the difference was not significant (p=0.43). Healthy pregnant women had a higher serum melatonin level (117.48±34.88 pg/ml) compared with the pregnant women with/without acute toxoplasmosis and a history of recurrent abortions. IL-10 serum level was higher in the healthy controls (12.73±2.58 pg/ml) as compared with the pregnant women with acute toxoplasmosis (5.50±1.92pg/ml) or without acute toxoplasmosis (8.50±2.53 pg/ml), (p0.0001). Serum melatonin level was positively correlated with serum IL-10 level (P0.001, r=0.94), and negatively correlated with serum IL-12 level in pregnant women with recurrent abortions with or without acute toxoplasmosis.Acute toxoplasmosis during pregnancy increases the risk of abortion through reduction of maternal serum melatonin level and dysregulation of pro-inflammatory/inflammatory cytokines axis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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