Treatment of Basal Cell Carcinoma Via Binary Ethosomes of Vismodegib: In Vitro and In Vivo Studies

Autor:	Amr Gamal, F, Ossama M, Sayed, Fatma I, Abo El-Ela, Rasha M, Kharshoum, Heba F, Salem
Rok vydání:	2019
Předmět:	Skin Neoplasms Treatment Outcome Carcinoma Basal Cell Pyridines Animals Humans Anilides Antineoplastic Agents Rats
Zdroj:	AAPS PharmSciTech. 21(2)
ISSN:	1530-9932
Popis:	Vismodegib (VMD) is a hedgehog inhibitor which indicated for basal cell skin cancer (BCC). This work focuses on investigating the influence of isopropyl alcohol additive for topical delivering and targeting of VMD-loaded binary ethosomes for BCC treatment. Different binary ethosome formulae were prepared based on Box-Behnken design using different concentrations of phospholipid (A), cholesterol (B) and isopropyl alcohol/total alcohol ratio (C). The prepared formulae were characterized for %entrapment efficiency (R
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::ed8866bfb1b99c76d57a42b032eac37b https://pubmed.ncbi.nlm.nih.gov/31900659 Zobrazit plný text záznamu Full text from SpringerLink