| Autor: |
Mattia Russel, Pantalone, Afsar, Rahbar, Cecilia, Söderberg-Naucler, Giuseppe, Stragliotto |
| Rok vydání: |
2022 |
| Zdroj: |
Cancers. 14(8) |
| ISSN: |
2072-6694 |
| Popis: |
Glioblastoma invariably recurs despite aggressive and multimodal first-line treatment and no standardized second-line therapy exists. We previously reported that treatment with the antiviral drug valganciclovir as an add-on to standard therapy significantly prolonged overall survival in 102 patients with newly diagnosed glioblastoma compared to contemporary controls. Here we present the results of retrospective survival analyses including patients with glioblastoma that initiated valganciclovir therapy after recurrence. Twenty-nine patients with recurrent glioblastoma received valganciclovir as an add-on to second-line therapy at Karolinska University Hospital. Contemporary controls were 109 patients with glioblastoma who received similar second-line therapy at our institution. We retrospectively analyzed survival data of these patients. Patients with recurrent glioblastoma who received valganciclovir had longer median overall survival after recurrence than controls (12.1 vs. 7.4 months, respectively |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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