| Autor: |
I E, Tareyeva, E M, Shilov, N B, Gordovskaya |
| Rok vydání: |
1980 |
| Předmět: |
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| Zdroj: |
Clinical nephrology. 14(5) |
| ISSN: |
0301-0430 |
| Popis: |
The effects of long-term treatment with azathioprine and prednisolone on T- and B-lymphocytes were studied in 52 patients with lupus nephritis (LN) and chronic glomerulonephritis (GN). The effect of azathioprine on lymphocyte populations was dose dependent; high doses decreased the number of T- and particularly, B-cells, while smaller doses produced a selective depletion of B-cells. The changes in T- and B-cells during prednisolone treatment were variable with alternating increases and decreases in their numbers. The patients with increased B-lymphocyte levels showed the best response to immunosuppressive therapy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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