Sex differences in the evolution of neutralizing antibodies to SARS-CoV-2
| Autor: | Grzelak, Ludivine, Velay, Aurélie, Madec, Yoann, Gallais, Floriane, Staropoli, Isabelle, Schmidt-Mutter, Catherine, Wendling, Marie-Josée, Meyer, Nicolas, Planchais, Cyril, Rey, David, Mouquet, Hugo, Reix, Nathalie, Glady, Ludovic, Hansmann, Yves, Bruel, Timothée, De Séze, Jérome, Fontanet, Arnaud, Gonzalez, Maria, Schwartz, Olivier, Fafi-Kremer, Samira |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | The Journal of Infectious Diseases |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | We measured anti-spike (S), nucleoprotein (N), and neutralizing antibodies in sera from 308 healthcare workers with a positive reverse-transcription quantitative polymerase chain reaction result for severe acute respiratory syndrome coronavirus 2 and with mild disease, collected at 2 timepoints up to 6 months after symptom onset. At month 1, anti-S and -N antibody levels were higher in male participants aged50 years and participants with a body mass index (BMI)25 kg/m2. At months 3-6, anti-S and anti-N antibodies were detected in 99% and 59% of individuals, respectively. Anti-S antibodies and neutralizing antibodies declined faster in men than in women, independent of age and BMI, suggesting an association of sex with evolution of the humoral response. |
| Databáze: | OpenAIRE |
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