| Autor: |
Rudolf A, Werner, Bilêl, Habacha, Susanne, Lütje, Lena, Bundschuh, Takahiro, Higuchi, Philipp, Hartrampf, Sebastian E, Serfling, Thorsten, Derlin, Constantin, Lapa, Andreas K, Buck, Markus, Essler, Kenneth J, Pienta, Mario A, Eisenberger, Mark C, Markowski, Laura, Shinehouse, Rehab, AbdAllah, Ali, Salavati, Martin A, Lodge, Martin G, Pomper, Michael A, Gorin, Ralph A, Bundschuh, Steven P, Rowe |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Molecular imaging. 2022 |
| ISSN: |
1536-0121 |
| Popis: |
In patients with prostate cancer (PC) receiving prostate-specific membrane antigen- (PSMA-) targeted radioligand therapy (RLT), higher baseline standardized uptake values (SUVs) are linked to improved outcome. Thus, readers deciding on RLT must have certainty on the repeatability of PSMA uptake metrics. As such, we aimed to evaluate the test-retest repeatability of lesion uptake in a large cohort of patients imaged withIn this prospective, IRB-approved trial (NCT03793543), 21 patients with history of histologically proven PC underwent twoIn total, 230 pairs of lesions (177 bone, 38 LN, and 15 other) were delineated, demonstrating a wide range of SUVIn this prospective test-retest setting, SUV parameters demonstrated high repeatability, in particular in LNs, while volumetric parameters demonstrated low repeatability. Further, the large number of lesions and wide distribution of SUVs included in this analysis allowed for the demonstration of a dependence of repeatability on SUV, with higher SUVs having more robust repeatability. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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