Relationship between epidermal growth factor receptor and other prognostic factors in gynecological cancers

Autor: M, Melpignano, E, Vadora, D, Debiasi, C, Merisio, S, Piombo, M, Brusati, L, Catozzi, G, Giovannini, A, Piffanelli, A, Merialdi
Rok vydání: 1993
Předmět:
Zdroj: Acta bio-medica de L'Ateneo parmense : organo della Societa di medicina e scienze naturali di Parma. 64(5-6)
Popis: In 62 cases of gynecological malignancies, 16 of the ovarian, 31 of the endometrium and 15 of the cervix, the EGF-R status was evaluated in order to establish its prognostic value and its correlation with other classical prognostic factors. We have failed to demonstrate any correlation between EGF-R status and stage, grade and hormonal receptors, ER/PgR, in ovarian and cervical cancer. In contrast, in endometrial cancer, we observed significantly lower levels of EGF-R in poorly differentiated tumors. Moreover, a weak negative relationship between EGF-R and PgR status was found. Regarding survival, we noticed a better prognosis in patients with ovarian cancer EGF-R positive, but without statistical significance.
Databáze: OpenAIRE