| Autor: |
Ye-Yi, Li, Man, Shang, Kun-Wei, Zhang, Su, Wei, Chao, Liu, Qian, Zhu, Jun-Yu, Zhao, Yan-Na, Wu, Jun-Qiu, Song, Yan-Xia, Liu |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. 34(2) |
| ISSN: |
1000-6834 |
| Popis: |
To investigate the effects of Astragaloside IV (AST) on diastolic function of rat thoracic aorta rings which was injured by microvesicles derived from hypoxia/reoxygenation (H/R)-treated human umbilical vein endothelial cells (HUVECs), and the mechanism of AST.H/R-induced endothelial microvesicles (H/R-EMVs) were generated from cultured HUVECsTenAST could effectively ameliorate endotheliumdependent relaxation of rat thoracic aortic rings impaired by H/R-EMVs in a concentration-dependent manner, the mechanism might involve the increase in production of NO, and the protein level of p-eNOS, p-Akt and p-ERK1/2. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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