[URINE UNDER CHRONIC DYSFUNCTION OF RENAL ALLO-TRANSPLANT]
| Autor: | A V, Trailin, M V, Pleten, A S, Nikonenko, N E, Efimenko, T I, Ostapenko |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Adolescent Interleukin-8 Alanine Transaminase gamma-Glutamyltransferase Middle Aged Alkaline Phosphatase Kidney Kidney Transplantation Interleukin-10 ROC Curve Acetylglucosaminidase Humans Interleukin-2 Transplantation Homologous Aspartate Aminotransferases Renal Insufficiency Chronic beta 2-Microglobulin Biomarkers Retrospective Studies |
| Zdroj: | Klinicheskaia laboratornaia diagnostika. 60(11) |
| ISSN: | 0869-2084 |
| Popis: | The study was organized to provide additional characteristic of chronic dysfunction of renal allo-transplant using such biomarkers of serum and urine as enzymes (alanine aminotransferase), aspartate aminotransferase, gamma- glutamiltransferase, alkaline phosphatase, N-acetyl-β-D-glucosaminidase, interleukins (IL-2, IL-8, IL-10), beta-2- microglobulin. The chronic dysfunction of renal allo-transplant is characterized by increasing of concentration of IL-10 and beta-2-microglobulin in serum and increasing of concentration of beta-2-microglobulin, IL-2, IL-8 in urine and increasing of activity of N-acetyl-β-D-glucosaminidase, alkaline phosphatase, aspartate aminotransferase, gamma-glutamiltransferase as compared with patients with satisfactory function of renal allo-transplant. The multivariant logistic regression analysis established that only activity of N-acetyl-β-D-glucosaminidase in urine was reliably independently related to chronic dysfunction of renal allo-transplant. It is assumed that increasing of concentration of beta-2-microglobulin in serum testifies glomerular dysfunction and in urine--tubular dysfunction of renal allo-transplant. The enzymeuria indicates continuing damage of epithelium of proximal tubules of nephron. The classification of patients with satisfactory function and chronic dysfunction of renal allo-transplant established that the highest indicators of square under ROC-curves had concentration of beta-2-microglobulin in serum (0.858 ± 0.061) and urine (0.733 ± 0.079) and activity of N-acetyl-β-D-glucosaminidase in urine (0.701 ± 0.061). To specify diagnosis of chronic dysfunction of renal allo-transplant the most useful (ratio of likelihood of positive result 10 and 11 correspondingly) are tests of beta-2- microglobulin in serum (more than 8.55 mkg/ml) and N-acetyl-β-D-glucosaminidase/creatinine in urine (more than 34 nmol/(sl)/ mmol/l). These discoveries require further validation and confirmation by implementation of morphological analysis of bioptat of renal allo-transplant. |
| Databáze: | OpenAIRE |
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