| Autor: |
Klaus P, Luef, Charlotte, Petit, Bettina, Ottersböck, Gernot, Oreski, Francis, Ehrenfeld, Bruno, Grassl, Stéphanie, Reynaud, Frank, Wiesbrock |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
European polymer journal |
| ISSN: |
0014-3057 |
| Popis: |
An 80-membered library of gels composed of monofunctional 2-ethyl-2-oxazoline and 2-nonyl-2-oxazoline and one of four selected difunctional 2-oxazolines (containing either ether or ester bonds) were synthesized by microwave-assisted ring-opening polymerizations. The difunctional 2-oxazolines were prepared from the thiol-ene reaction of glycol dimercaptoacetate or 2,2′-(ethylenedioxy)diethanethiol and 2-but-3′-enyl-2-oxazoline or 2-dec-9′-enyl-2-oxazoline. 53 of the gels exhibited glass-transition temperatures, which ranged from −5.9 to 45.3 °C. 13 Derivatives exhibited glass-transition temperatures in the range from 20 to 30 °C, which renders them stiff at room temperature and flexible at body temperature. The gels that did not contain any 2-ethyl-2-oxazoline acted as lipogels, whereas the gels that did not contain any 2-nonyl-2-oxazoline acted as hydrogels; all other gels may be classified as amphigels. The swelling degrees were measured by gravimetry and maximum swelling degrees of 6 (in water) were observed for the gels with the lowest degrees of crosslinking. In a second approach, the synthesis of crosslinked networks had been achieved by performing the polymeranalogous thiol-ene reaction of copoly(2-oxazoline)s containing olefinic side-chains and glycol dimercaptoacetate. This soft strategy enabled the straightforward loading of such gels with active pharmaceutical ingredients without altering them. This method delivered gels with selected composition exhibiting a targeted disc-shape and loaded with active pharmaceutical ingredients from one-step syntheses. The maximum swelling degrees of these specimens were found to be in accordance with the ones from the first route investigated. Preliminary degradation studies were performed at 25 °C; these types of gels were found to be degraded in alkaline media as well as by esterases. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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