| Autor: |
Kathrin, Warnking, Carolin, Klemm, Bettina, Löffler, Silke, Niemann, Andre, van Krüchten, Georg, Peters, Stephan, Ludwig, Christina, Ehrhardt |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Cellular microbiology. 17(3) |
| ISSN: |
1462-5822 |
| Popis: |
Bacterial super-infections are a major complication in influenza virus-infected patients. In response to infection with influenza viruses and bacteria, a complex interplay of cellular signalling mechanisms is initiated, regulating the anti-pathogen response but also pathogen-supportive functions. Here, we show that influenza viruses replicate to a higher efficiency in cells co-infected with Staphylococcus aureus (S. aureus). While cells initially respond with increased induction of interferon beta upon super-infection, subsequent interferon signalling and interferon-stimulated gene expression are rather impaired due to a block of STAT1-STAT2 dimerization. Thus, S. aureus interrupts the first line of defence against influenza viruses, resulting in a boost of viral replication, which may lead to enhanced viral pathogenicity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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