| Autor: |
Jayanta, Mukherjee, Ross A, Cardarelli, Yasmine, Cantaut-Belarif, Tarek Z, Deeb, Deepak P, Srivastava, Shiva K, Tyagarajan, Menelas N, Pangalos, Antoine, Triller, Jamie, Maguire, Nicholas J, Brandon, Stephen J, Moss |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America. 114(44) |
| ISSN: |
1091-6490 |
| Popis: |
Our knowledge of how estrogen signaling can influence inhibitory synaptic transmission is rudimentary and is addressed here. Collectively, our data suggest that estrogen modulates the dynamics of surface GABAA receptors and hence efficacy of synaptic inhibition, via a postsynaptic mechanism that relies on disrupting the postsynaptic scaffold. This regulatory mechanism may have profound effects on the efficacy of neuronal inhibition and therefore synaptic plasticity and thus play a role in the pathophysiology of estrogen-related seizure and cognitive disorders. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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