Real-time tissue elastography: non-invasive evaluation of liver fibrosis in chronic liver disease due to HCV
| Autor: | Akiko, Shiraishi, Atsushi, Hiraoka, Toshihiko, Aibiki, Tomonari, Okudaira, Tomoe, Kawamura, Yusuke, Imai, Haruka, Tatsukawa, Hiroka, Yamago, Hiromasa, Nakahara, Yuko, Shimizu, Yoshihumi, Suga, Nobuaki, Azemoto, Tetsuya, Tanihira, Hideki, Miyata, Yasunao, Miyamoto, Tomoyuki, Ninomiya, Masashi, Hirooka, Masanori, Abe, Yoichi, Hiasa, Bunzo, Matsuura, Hideki, Kawasaki, Keizo, Furuya, Kojiro, Michitaka |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Liver Cirrhosis Male Platelet Count Biopsy Hepatitis C Chronic Middle Aged Severity of Illness Index Decision Support Techniques Young Adult Liver ROC Curve Predictive Value of Tests Area Under Curve Case-Control Studies Elasticity Imaging Techniques Humans Female Aspartate Aminotransferases Biomarkers Aged |
| Zdroj: | Hepato-gastroenterology. 61(135) |
| ISSN: | 0172-6390 |
| Popis: | We evaluated the diagnostic efficacy for advanced fibrosis of real-time tissue elastography (RTE), is a newly introduced non-invasive method, in hepatitis C virus (HCV) patients.Sixty-six chronic liver diseases with HCV (CLD-HCV) were evaluated by RTE, FIB-4, and APRI, as well as biopsy or hepatectomy findings. Seventeen healthy volunteers, and 1 with elevation of transaminase and 5 with liver tumors within their normal liver were enrolled for normal controls. Severe fibrosis was defined as METAVIR score 3 or 4. The tissue elasticity value was expressed by LF-index created by the program incorporated in the ultrasound device. The percentage of fibrosis area in each specimen (%FA) was determined with a personal computer. A receiver operating characteristic curve (ROC) was calculated for each non-invasive method of estimation of fibrosis.The values for the area under the ROC for LF-index, APRI, and FIB-4 were 0.88, 0.81, and 0.84, respectively. Accuracy, sensitivity, and specificity for prediction of LF-index (2.8) for severe fibrosis were 86.5%, 78.6%, and 93.6%, respectively, which were better than those of FIB-4 and APRI. LF-index showed a good relationship to %FA (r=0.276, P=0.020).RTE is an effective method for predicting severe fibrosis in CLD-HCV. |
| Databáze: | OpenAIRE |
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