| Autor: |
Yonghong, Lei, Yanping, Yang, Jieqiong, Zhao, Haibo, Gao, Ruirui, Chen, Baobao, Bai, Xiaohui, Kang, Yong, He, Lu, Ding, Ting, Wei, Xiaobing, Fu, Lianyou, Zhao, Xue, Li |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
American journal of translational research. 11(5) |
| ISSN: |
1943-8141 |
| Popis: |
Macrophage recruitment to the inflammation site is essential for LPS-induced myocarditis, although the underlying mechanism remains elusive. This study was designed to examine the role of the P-AKT2/SPK1 (P-SPK1) and P-MEK/P-ERK signaling cascades in the regulation of macrophage migration and LPS-induced myocarditis. Our data revealed that (1) the P-AKT2/SPK1 (P-SPK1) and P-MEK/P-ERK signaling cascades acted separately in the regulation of macrophage migration; (2) P-AKT2/SPK1 (P-SPK1) played a relatively important role compared to P-MEK/P-ERK cell signaling in LPS-induced macrophage migration; (3) atorvastatin (ATV) inhibited macrophage migration by inhibiting P-AKT2/SPK1 (P-SPK1) cell signaling, but ATV could increase P-MEK and P-ERK protein expression; (4) ATV has a beneficial effect on LPS-induced myocarditis via inhibition of P-AKT2/SPK1-mediated macrophage recruitment, apoptosis, TNFα, IL-1β, and IL-6; (5) ATV-offered protection against LPS-induced myocarditis was eliminated from SPK1-KO mice; (6) SPK1 may play a harmful role in LPS-induced myocarditis. Taken together, our data revealed that SPK1 represents a novel regulating factor for macrophage migration and cardiac protection under LPS-induced myocarditis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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