| Autor: |
Dean, Thumkeo, Siwakorn, Punyawatthananukool, Somsak, Prasongtanakij, Ryuma, Matsuura, Kentaro, Arima, Huan, Nie, Rie, Yamamoto, Naohiro, Aoyama, Hisao, Hamaguchi, Shingo, Sugahara, Shinobu, Takeda, Varodom, Charoensawan, Atsushi, Tanaka, Shimon, Sakaguchi, Shuh, Narumiya |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Cell reports. 39(10) |
| ISSN: |
2211-1247 |
| Popis: |
Active inflammation generally promotes immune activation. However, in the tumor microenvironment (TME), active inflammation occurs in parallel with immunosuppression, and both contribute to tumor growth. Why inflammation does not lead to immune activation in TME remains unclear. In this study, using the immune checkpoint inhibitor-insensitive mouse cancer model and single-cell RNA sequencing, we show that PGE |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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