Reproducibility studies with 11C-DTBZ, a monoamine vesicular transporter inhibitor in healthy human subjects
| Autor: | G L, Chan, J E, Holden, A J, Stoessl, A, Samii, D J, Doudet, T, Dobko, K S, Morrison, M, Adam, M, Schulzer, D B, Calne, T J, Ruth |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Neurotransmitter Agents Membrane Glycoproteins Neuropeptides Tetrabenazine Brain Membrane Transport Proteins Reproducibility of Results Middle Aged Cerebellum Vesicular Biogenic Amine Transport Proteins Vesicular Monoamine Transport Proteins Humans Female Carbon Radioisotopes Occipital Lobe Radiopharmaceuticals Aged Tomography Emission-Computed |
| Zdroj: | Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 40(2) |
| ISSN: | 0161-5505 |
| Popis: | The reproducibility of (+/-)-alpha-[11C] dihydrotetrabenazine (DTBZ) measures in PET was studied in 10 healthy human subjects, aged 22-76 y.The scan-to-scan variation of several measures used in PET data analysis was determined, including the radioactivity ratio (target-to-reference), plasma-input Logan total distribution volume (DV), plasma-input Logan Bmax/Kd and tissue-input Logan Bmax/Kd values.The radioactivity ratios, plasma-input Bmax/Kd and tissue-input Bmax/Kd all have higher reliability than plasma-input total DV values. In addition, measures using the occipital cortex as the reference region have higher reliability than the same measures using the cerebellum as the reference region.Our results show that DTBZ is a reliable PET tracer that provides reproducible in vivo measurement of striatal vesicular monoamine transporter density. In the selection of reference regions for DTBZ PET data analysis, caution must be exercised in circumstances when DTBZ binding in the occipital cortex or the cerebellum may be altered. |
| Databáze: | OpenAIRE |
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