[Imbalance in the proteinase-inhibitor system in obstetric sepsis and septic shock]

Autor: L A, Belova, O G, Ogloblina, A A, Satalkin, A N, Diugeev, M D, Fomin, L G, Kashina, V V, Kukharchuk
Rok vydání: 2003
Předmět:
Zdroj: Klinicheskaia laboratornaia diagnostika. (7)
ISSN: 0869-2084
Popis: The condition of proteinase-inhibitor balance was studied in blood plasma of patients with obstetric sepsis. Hypoproteinemia (due to a massive blood loss and toxic effect) was shown to result in a 2-5-fold decrease of the activity of endogenous proteinases in blood plasma versus the control group. The activity of alpha-macroglobulins was also by 2 times lower versus the controls, while the activity of alpha 1-antichymotrypsin and of an acid-stable inhibitor of trypsin was found to be higher by 20-30%. A degree of imbalance of proteinase/inhibitor depends on a disease severity.
Databáze: OpenAIRE