Endothelial Ca
| Autor: | Francesco, Moccia, Sharon, Negri, Mudhir, Shekha, Pawan, Faris, Germano, Guerra |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
endothelial colony forming cells
Neovascularization Pathologic vascular endothelial growth factor Endothelial Cells Neovascularization Physiologic Review basic fibroblast growth factor stromal derived factor-1α TRPC channels inositol-1 4 5-trisphosphate Gene Expression Regulation Animals Cytokines Humans Intercellular Signaling Peptides and Proteins Calcium Calcium Signaling Endothelium Chemokines nicotinic acid adenine dinucleotide phosphate Biomarkers store-operated Ca2+ entry |
| Zdroj: | International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| Popis: | It has long been known that endothelial Ca2+ signals drive angiogenesis by recruiting multiple Ca2+-sensitive decoders in response to pro-angiogenic cues, such as vascular endothelial growth factor, basic fibroblast growth factor, stromal derived factor-1α and angiopoietins. Recently, it was shown that intracellular Ca2+ signaling also drives vasculogenesis by stimulation proliferation, tube formation and neovessel formation in endothelial progenitor cells. Herein, we survey how growth factors, chemokines and angiogenic modulators use endothelial Ca2+ signaling to regulate angiogenesis and vasculogenesis. The endothelial Ca2+ response to pro-angiogenic cues may adopt different waveforms, ranging from Ca2+ transients or biphasic Ca2+ signals to repetitive Ca2+ oscillations, and is mainly driven by endogenous Ca2+ release through inositol-1,4,5-trisphosphate receptors and by store-operated Ca2+ entry through Orai1 channels. Lysosomal Ca2+ release through nicotinic acid adenine dinucleotide phosphate-gated two-pore channels is, however, emerging as a crucial pro-angiogenic pathway, which sustains intracellular Ca2+ mobilization. Understanding how endothelial Ca2+ signaling regulates angiogenesis and vasculogenesis could shed light on alternative strategies to induce therapeutic angiogenesis or interfere with the aberrant vascularization featuring cancer and intraocular disorders. |
| Databáze: | OpenAIRE |
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