| Autor: |
R K, Türker, S, Kaymakcalan, Z S, Ercan |
| Rok vydání: |
1975 |
| Předmět: |
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| Zdroj: |
Archives internationales de pharmacodynamie et de therapie. 214(2) |
| ISSN: |
0003-9780 |
| Popis: |
THC has an antagonistic effect against histamine on the isolated perfused guinea-pig lung and rabbit kidney. This antagonism seems to be a competitive one at the concentrations used and interacts with histamine at H1-receptors. THC also antagonizes the effect of acetylcholine, PGE2, angiotensis II and histamine in the isolated continuously superfused guinea-pig ileum by a non-competitive manner. The antagonism between THC and histamine on the isolated superfused rabbit aortic strips was found to be highly specific, since 100% relaxation was obtained when the muscle contracted by histamine but not by the equipotent doses of angiotensin II and noradrenaline. THC also causes a significant increase in survival time of guinea-pigs when the animals were exposed to histamine aerosol. These results indicate a specific antagonism of THC against histamine in the preparations used in this investigation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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