| Autor: |
Julien, Lalut, Gianluca, Santoni, Delphine, Karila, Cédric, Lecoutey, Audrey, Davis, Florian, Nachon, Israel, Silman, Joel, Sussman, Martin, Weik, Tangui, Maurice, Patrick, Dallemagne, Christophe, Rochais |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
European journal of medicinal chemistry. 162 |
| ISSN: |
1768-3254 |
| Popis: |
Pleiotropic intervention may be a requirement for effective limitation of the progression of multifactorial diseases such as Alzheimer's Disease. One approach to such intervention is to design a single chemical entity capable of acting on two or more targets of interest, which are accordingly known as Multi-Target Directed Ligands (MTDLs). We recently described donecopride, the first MTDL able to simultaneously inhibit acetylcholinesterase and act as an agonist of the 5-HT |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full Text from ScienceDirect