| Autor: |
Fabiana, Napolitano, Sarah, Di Somma, Giuliano, Castellano, Jussara, Amato, Bruno, Pagano, Antonio, Randazzo, Giuseppe, Portella, Anna Maria, Malfitano |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Cells. 11(16) |
| ISSN: |
2073-4409 |
| Popis: |
G-quadruplexes (G4s) are nucleic secondary structures characterized by G-tetrads. G4 motif stabilization induces DNA damage and cancer cell death; therefore, G4-targeting small molecules are the focus of clinical investigation. DNA destabilization induced by G4 ligands might potentiate the anticancer activity of agents targeting DNA or inhibiting its repair such as oncolytic viruses. This study represents the first approach combining G4 ligands, BRACO-19 (B19), pyridostatin (PDS), and the adenovirus |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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