[P-glycoprotein expression in radiation-associated acute myeloid leukemia]
| Autor: | V H, Bebeshko, D A, Bazyka, S V, Klymenko, O L, Maznichenko, N A, Holiarnik, O V, Liaskovs'ka, I M, Il'ienko, N M, Tretiak, O O, Vdovtsov, T M, Serbinenko, T B, Zubryts'ka, V N, Zinchenko |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Aged 80 and over Leukemia Radiation-Induced Male Bone Marrow Cells Middle Aged Flow Cytometry Survival Analysis Chernobyl Nuclear Accident Leukemia Myeloid Acute Disease Leukocytes Humans Female ATP Binding Cassette Transporter Subfamily B Member 1 Fluorescent Antibody Technique Indirect Ukraine Aged |
| Zdroj: | Likars'ka sprava. (3) |
| ISSN: | 1019-5297 |
| Popis: | The article presents findings of the analysis on P-glycoprotein expression of leukemic cells in 52 acute myeloid leukemia (AML) patients. Of these, there were 20 persons exposed to ionizing radiation due to the Chernobyl accident and 32 patients with spontaneous disease. Leukemic cells in patients with radiation-associated AML compared to spontaneous cases more often were P-glycoprotein positive (12/20 vs 9/32, P0,05). P-glycoprotein overexpression significantly correlated with resistant disease in patients with radiation-associated AML, but was not a prognostic variable for treatment outcome in terms of overall survival. |
| Databáze: | OpenAIRE |
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