Frailty in Older Adults Undergoing Aortic Valve Replacement: The FRAILTY-AVR Study
| Autor: | Jonathan, Afilalo, Sandra, Lauck, Dae H, Kim, Thierry, Lefèvre, Nicolo, Piazza, Kevin, Lachapelle, Giuseppe, Martucci, Andre, Lamy, Marino, Labinaz, Mark D, Peterson, Rakesh C, Arora, Nicolas, Noiseux, Andrew, Rassi, Igor F, Palacios, Philippe, Généreux, Brian R, Lindman, Anita W, Asgar, Caroline A, Kim, Amanda, Trnkus, José A, Morais, Yves, Langlois, Lawrence G, Rudski, Jean-Francois, Morin, Jeffrey J, Popma, John G, Webb, Louis P, Perrault |
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| Rok vydání: | 2017 |
| Předmět: |
Aged
80 and over Male Canada Frail Elderly Aortic Valve Stenosis Risk Assessment Severity of Illness Index United States Survival Rate Transcatheter Aortic Valve Replacement Treatment Outcome Risk Factors Aortic Valve Heart Valve Prosthesis Odds Ratio Humans Female France Prospective Studies Aged Follow-Up Studies |
| Zdroj: | Journal of the American College of Cardiology. 70(6) |
| ISSN: | 1558-3597 |
| Popis: | Frailty is a geriatric syndrome that diminishes the potential for functional recovery after a transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (SAVR) procedure; however, its integration in clinical practice has been limited by a lack of consensus on how to measure it.This study sought to compare the incremental predictive value of 7 different frailty scales to predict poor outcomes following TAVR or SAVR.A prospective cohort of older adults undergoing TAVR or SAVR was assembled at 14 centers in 3 countries from 2012 to 2016. The following frailty scales were compared: Fried, Fried+, Rockwood, Short Physical Performance Battery, Bern, Columbia, and the Essential Frailty Toolset (EFT). Outcomes of interest were all-cause mortality and disability 1 year after the procedure.The cohort was composed of 1,020 patients with a median age of 82 years. Depending on the scale used, the prevalence of frailty ranged from 26% to 68%. Frailty as measured by the EFT was the strongest predictor of death at 1 year (adjusted odds ratio [OR]: 3.72; 95% confidence interval [CI]: 2.54 to 5.45) with a C-statistic improvement of 0.071 (p 0.001) and integrated discrimination improvement of 0.067 (p 0.001). Moreover, the EFT was the strongest predictor of worsening disability at 1 year (adjusted OR: 2.13; 95% CI: 1.57 to 2.87) and death at 30 days (adjusted OR: 3.29; 95% CI: 1.73 to 6.26).Frailty is a risk factor for death and disability following TAVR and SAVR. A brief 4-item scale encompassing lower-extremity weakness, cognitive impairment, anemia, and hypoalbuminemia outperformed other frailty scales and is recommended for use in this setting. (Frailty Assessment Before Cardiac SurgeryTranscatheter Interventions; NCT01845207). |
| Databáze: | OpenAIRE |
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