| Autor: |
Kristian, Berg, Maria, Berstad, Lina, Prasmickaite, Anette, Weyergang, Pål K, Selbo, Ida, Hedfors, Anders, Høgset |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
Topics in current chemistry. 296 |
| ISSN: |
0340-1022 |
| Popis: |
Photochemical internalization (PCI) is a novel technology for release of endocytosed macromolecules into the cytosol. The technology is based on the use of photosensitizers located in endocytic vesicles. Upon activation by light such photosensitizers induce a release of macromolecules from their compartmentalization in endocytic vesicles. PCI has been shown to increase the biological activity of a large variety of macromolecules and other molecules that do not readily penetrate the plasma membrane, including type I ribosome-inactivating proteins, immunotoxins, plasmids, adenovirus, various oligonucleotides, dendrimer-based delivery of chemotherapeutica and unconjugated chemotherapeutica such as bleomycin and doxorubicin. This review will present the basis for the PCI concept and the most recent significant developments. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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