| Autor: |
Ingrid, Marton, Fabijan, Knezevic, Snjezana, Ramic, Milan, Milosevic, Davor, Tomas |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
Anticancer research. 32(12) |
| ISSN: |
1791-7530 |
| Popis: |
To determine the predictive value of HIF-1α and VEGF-C in primary neuroendocrine breast cancers (NEBC) and their correlation with other clinico-pathological characteristics of NEBC.HIF-1α and VEGF-C were determined immunohistochemically in tissue samples from 31 cases of NEBC.The HIF-1α expression in NEBC was predominantly negative, with only 5 (16.1%) cases showing strong reaction to HIF-1α. Eighteen (58.0%) NEBC cases showed moderate-to-strong VEGF-C expression. VEGF-C expression negatively correlated with progesterone receptor positivity (p=0.014) and duration of follow-up (p=0.021). A multivariate Cox proportional hazard regression analysis showed that HIF-1α (p=0.019) was a significant predictor of disease-free survival, whereas VEGF-C (p=0.099) showed no such association.HIF-1α overexpression indicated unfavourable prognosis and could serve as an additional prognostic factor in NEBC. Moreover, patients with NEBC exhibiting moderate or strong VEGF-C expression could be candidates for a specific VEGF-C antibody therapy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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