Corticonuclear projections of the cerebellum preserve both anteroposterior and mediolateral pairing patterns

Autor:	M R, Pantò, A, Zappalà, R, Parenti, M F, Serapide, F, Cicirata
Rok vydání:	2001
Předmět:	Nerve Fibers Cerebellar Nuclei Cerebellum Neural Pathways Morphogenesis Animals Biotinylation Rats Wistar Axonal Transport Fluorescent Dyes Injections Rats
Zdroj:	The European journal of neuroscience. 13(4)
ISSN:	0953-816X
Popis:	The aim of the present study was to establish whether a diverging arrangement of the corticonuclear cerebellar projections exists and, if so, what relation it has with the inferior olivary complex. Iontophoretic injections of a 1 : 1 mixture of tetramethylrhodamine dextran amine and biotinylated dextran amine into the cerebellar cortex orthogradely labelled fibre terminals in the cerebellar nuclei and retrogradely labelled cell bodies in the inferior olivary complex. The injections were into A, B, C2, C3, D1 and D2 bands. These injections showed diverging projections to the cerebellar nuclei, with 'primary projections' directed to the nuclear region previously reported to be specifically connected with the injected band and 'secondary projections' directed to other nuclear regions. Secondary projections from the A, C2 and C3 bands diverged to nuclear regions primarily controlled by cortical bands lateral to those injected. Secondary projections from the D1, and D2 bands diverged to nuclear regions primarily controlled by cortical bands medial to those injected. Moreover, injections distributed along the D1 and D2 bands showed similar sets of nuclear targets, while those distributed along the A, C2 and C3 bands showed two sets of nuclear targets in relation to the anteroposterior location of the injected area within these bands. The cortical areas that projected to the same set of nuclear targets were innervated from single olivary regions, while those that projected to different sets of nuclear targets were innervated from different subsets of single regions of the inferior olive. The results suggest that the olivary bands of the cerebellar cortex project to the cerebellar nuclei with a diverging pattern that is organized in both the mediolateral and the anteroposterior axes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::d8be3b8b2339bf6d71afb2f45736ee25 https://pubmed.ncbi.nlm.nih.gov/11207805 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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