| Autor: |
Esteban M, Lucero, Ronald K, Freund, Alexandra, Smith, Noah R, Johnson, Breanna, Dooling, Emily, Sullivan, Olga, Prikhodko, Md Mahiuddin, Ahmed, David A, Bennett, Timothy J, Hohman, Mark L, Dell'Acqua, Heidi J, Chial, Huntington, Potter |
| Rok vydání: |
2022 |
| Zdroj: |
iScience. 25(11) |
| ISSN: |
2589-0042 |
| Popis: |
Previously, we found that amyloid-beta (Aβ) competitively inhibits the kinesin motor protein KIF11 (Kinesin-5/Eg5), leading to defects in the microtubule network and in neurotransmitter and neurotrophin receptor localization and function. These biochemical and cell biological mechanisms for Aβ-induced neuronal dysfunction may underlie learning and memory defects in Alzheimer's disease (AD). Here, we show that KIF11 overexpression rescues Aβ-mediated decreases in dendritic spine density in cultured neurons and in long-term potentiation in hippocampal slices. Furthermore |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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