| Autor: |
C, Ozaslan, A G, Türkçapar, M, Kesenci, K, Karayalçin, M A, Yerdel, S, Bengisun, A, Törüner |
| Rok vydání: |
1997 |
| Předmět: |
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| Zdroj: |
The European journal of surgery = Acta chirurgica. 163(6) |
| ISSN: |
1102-4151 |
| Popis: |
To find out if lactulose can prevent the bacterial translocation that is induced by obstructive jaundice in rats.Laboratory experiment.Teaching hospital, Turkey.50 male Wistar-albino rats.10 rats were not operated on and used as controls; 20 rats underwent laparotomy and sham ligation of the common bile duct (CBD); 20 had the CBD ligated alone; and 20 had the CBD ligated and were given oral lactulose 2 ml/day until death. All rats were killed after 14 days.Presence of Escherichia coli in mesenteric lymph nodes (MLN), and bacterial overgrowth as indicated by counts of E coli in the caecum.There was significantly less bacterial translocation to MLN in the group that had been given lactulose compared with CBD-ligated and lactulose not given (2/20 compared with 8/20, p = 0.06). There was also a significant reduction in the number of Gram negative bacteria in that group (p =0.01).Lactulose seems to reduce the incidence of translocation from the gut to MLN in rats with obstructive jaundice. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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