| Autor: |
Natalia, Fernández-Borges, Hasier, Eraña, Saioa R, Elezgarai, Chafik, Harrathi, Vanesa, Venegas, Joaquín, Castilla |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Methods in molecular biology (Clifton, N.J.). 1658 |
| ISSN: |
1940-6029 |
| Popis: |
Prion diseases or transmissible spongiform encephalopathies (TSEs) are a group of neurodegenerative diseases where the misfolding of the prion protein (PrP) is a crucial event. Based on studies in TSE-affected humans and the generation of transgenic mouse models overexpressing different mutated versions of the PrP, we conclude that both wild-type and mutated PrPs exhibit differential propensity to misfold in vivo. Here, we describe a new method in vitro to assess and quantify the PrP misfolding phenomenon in order to better understand the molecular mechanisms involved in this process. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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