[Present state and prospects of adjuvant chemotherapy for gastric cancer]

Autor: Takaaki, Hori, Rie, Ozawa, Hiroyuki, Hanayama, Hidetaka, Yamashita, Noriaki, Kaibe, Tomohiro, Matsumoto, Tsutomu, Oshima, Masashi, Takemura, Shojiro, Kikuchi, Mitsuru, Sasako
Rok vydání: 2011
Předmět:
Zdroj: Gan to kagaku ryoho. Cancerchemotherapy. 38(9)
ISSN: 0385-0684
Popis: In Japan, a one-year administration of S-1 is the standard adjuvant treatment for stage II/III gastric cancer after curative gastrectomy with a D2 lymph-node dissection.The treatment is recommended in the Japanese Guidelines for Treatment of Gastric Cancer(3rd Edition).Using data from results of a 5-year follow-up of the ACTS-GC trial, it was confirmed that using S-1 significantly improves the 5-year overall survival over surgery alone.However, the recurrence rate of stage III gastric cancer is still too high.More powerful treatment using multiple drugs is needed for this disease.This paper presents a new perspective for the development of post-operative adjuvant chemotherapy in the future, based on clinical trials recently reported.
Databáze: OpenAIRE