| Autor: |
Jiang-Xue, Hou, Shu-Juan, Wang, Yan-Fang, Liu, Qian-Qian, Hao, Chong, Wang, Tao, Li, Jun-Jun, Bai, Lin-Xiao, Liao, Cheng-Yu, Guo, Yin-Yin, Chang, Meng, Wang, Hui, Sun, Xin-Sheng, Xie, Zhong-Xing, Jiang |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Zhongguo shi yan xue ye xue za zhi. 27(2) |
| ISSN: |
1009-2137 |
| Popis: |
To investigate the clinical features, accompanying gene mutation characteristics and prognostic factors of adult patients with acute myeloid leukemia with mutated NPM1 (NPM1Seventy-three patients with newly diagnosed adult NPM1A total of 74 NPM1 site mutations were detected in 73 patients with NPM1The NPM1 gene mutation in AML patients often is accompanied by other gene mutations, while the coexistence of fusion genes is rare; high NPM1 mutant allele burden is an independent prognostic factor for adult AML patients with mutated NPM1.NPM1高突变负荷是NPM1阳性急性髓系白血病患者的预后不良因素.探讨NPM1基因突变阳性成人急性髓系白血病（NPM1收集并应用第二代测序法测定22种AML常见的基因突变中NPM1基因突变阳性初诊成人AML患者73例，用实时荧光定量PCR法测定43种AML常见的融合基因，应用Kaplan-Meier生存曲线和Cox多因素回归分析影响预后的因素。.73例NPM1AML患者NPM1基因突变常伴随其它基因突变，但罕有融合基因并存；NPM1高突变负荷是NPM1阳性成人AML患者的独立预后不良因素。. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
