Quantitative neuroimaging measures of myelin in the healthy brain and in multiple sclerosis
| Autor: | Jonathan, O'Muircheartaigh, Irene, Vavasour, Emil, Ljungberg, David K B, Li, Alexander, Rauscher, Victoria, Levesque, Hideki, Garren, David, Clayton, Roger, Tam, Anthony, Traboulsee, Shannon, Kolind |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male magnetization transfer ratio relaxometry Brain Neuroimaging Middle Aged multiple sclerosis Magnetic Resonance Imaging quantitative MRI myelin water imaging Young Adult myelin Multiple Sclerosis Relapsing-Remitting Humans Female individual differences Myelin Sheath Research Articles Research Article |
| Zdroj: | Human Brain Mapping |
| ISSN: | 1097-0193 |
| Popis: | Quantitative magnetic resonance imaging (MRI) techniques have been developed as imaging biomarkers, aiming to improve the specificity of MRI to underlying pathology compared to conventional weighted MRI. For assessing the integrity of white matter (WM), myelin, in particular, several techniques have been proposed and investigated individually. However, comparisons between these methods are lacking. In this study, we compared four established myelin‐sensitive MRI techniques in 56 patients with relapsing–remitting multiple sclerosis (MS) and 38 healthy controls. We used T2‐relaxation with combined GRadient And Spin Echoes (GRASE) to measure myelin water fraction (MWF‐G), multi‐component driven equilibrium single pulse observation of T1 and T2 (mcDESPOT) to measure MWF‐D, magnetization‐transfer imaging to measure magnetization‐transfer ratio (MTR), and T1 relaxation to measure quantitative T1 (qT1). Using voxelwise Spearman correlations, we tested the correspondence of methods throughout the brain. All four methods showed associations that varied across tissue types; the highest correlations were found between MWF‐D and qT1 (median ρ across tissue classes 0.8) and MWF‐G and MWF‐D (median ρ = 0.59). In eight WM tracts, all measures showed differences (p |
| Databáze: | OpenAIRE |
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