Protective effect of an oestrogen against endotoxin-induced liver enzyme release

Autor:	Carbarns, N. J., Neale, M. L., Stark, J. M.
Jazyk:	angličtina
Rok vydání:	1993
Předmět:	Male Mice Inbred BALB C Dose-Response Relationship Drug Estrone Superoxide Dismutase Tumor Necrosis Factor-alpha Alanine Transaminase Drug Administration Schedule Endotoxins Kinetics Mice Liver Animals Vitamin E Research Article
Popis:	Groups of mice were given oestrone acetate or vitamin E subcutaneously to determine how these treatments might modify responses to endotoxic lipopolysaccharide given intraperitoneally. Release of hepatic transaminase and tumour necrosis factor (TNF) into serum and induction of manganous superoxide dismutase in the liver were measured. Significantly less transaminase and TNF were released into the circulation in mice given the steroid or vitamin E before the endotoxin. In endotoxin-treated animals oestrogen administration did not influence induction of the superoxide dismutase. It is postulated that protection of the liver in these experiments arises from a direct pharmacological antioxidant effect of the oestrogen.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::d37a08e5831dd463e53baba924f53ffd https://europepmc.org/articles/PMC2002169/ Zobrazit plný text záznamu