Complete response of brain metastases from breast cancer overexpressing Her-2/neu to radiation and concurrent Lapatinib and Capecitabine

Autor:	Mirna, Abboud, Nagi S El, Saghir, Joseph, Salame, Fady B, Geara
Rok vydání:	2010
Předmět:	Brain Neoplasms Receptor ErbB-2 Breast Neoplasms Lapatinib Radiotherapy Dosage Middle Aged Combined Modality Therapy Deoxycytidine Antineoplastic Combined Chemotherapy Protocols Quinazolines Humans Female Fluorouracil Capecitabine
Zdroj:	The breast journal. 16(6)
ISSN:	1524-4741
Popis:	Breast cancers that overexpress the human epidermal growth factor receptor 2 (HER-2) have a predilection to metastasize to the brain. Therapeutic options for brain metastases with systemic therapy remain a challenge in those patients since targeted and chemotherapeutic agents have limited penetration through the blood-brain barrier. Here we report the case of a patient with brain metastases from breast cancer overexpressing HER-2 who achieved a complete radiologic response after treatment by radiation and concurrent Lapatinib and Capecitabine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::d2d963d1ffbebe322defe0de4803e582 https://pubmed.ncbi.nlm.nih.gov/21070441 Zobrazit plný text záznamu Plný text ve formátu PDF