| Autor: |
A S, Wierzbicki, T C, Hardman, P, Lumb, A, Sankaralingam, Z, Morrish, F, Patel, M C, Sidey, F B, Gibberd |
| Rok vydání: |
1998 |
| Předmět: |
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| Zdroj: |
European journal of clinical investigation. 28(4) |
| ISSN: |
0014-2972 |
| Popis: |
Abnormal behaviour of the erythrocyte membrane sodium-lithium countertransporter (SLC) is associated with plasma triglyceride concentrations. Refsum's disease is characterized by progressive neurological dysfunction and accumulation of phytanic acid, an isoprenoid fatty acid, in fat-containing tissues.This study explored the effects of plasma phytanic acid on SLC kinetics in nine Caucasian patients with Refsum's disease and in age- and sex-matched Caucasian control subjects.A dose-dependent association was seen between countertransporter maximal velocity and phytanic acid content of low-density lipoprotein (LDL)-cholesterol (r = -0.61, r = -0.65 respectively; P = 0.05, P = 0.04) and high-density lipoprotein (HDL)-cholesterol (r = -0.81, -0.82 respectively; P = 0.005, P = 0.003). No significant association was seen with the sodium affinity of the transporter (r = -0.44, P = 0.20, for LDL; and -0.43, P = 0.21, for high-density lipoprotein).These findings suggest that phytanic acid may alter the behaviour of the sodium-lithium countertransporter. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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