Suppression of growth and transformation and induction of apoptosis by EGR-1

Autor:	C, Liu, V M, Rangnekar, E, Adamson, D, Mercola
Rok vydání:	1998
Předmět:	DNA-Binding Proteins Transcriptional Activation Cell Transformation Neoplastic Transforming Growth Factor beta Animals Humans Apoptosis Zinc Fingers Early Growth Response Protein 1 Immediate-Early Proteins Transcription Factors
Zdroj:	Cancer gene therapy. 5(1)
ISSN:	0929-1903
Popis:	Although cloned as an "immediate-early gene," recent studies show that EGR-1 functions in growth regulation and suppression of transformation by transactivation of the transforming growth factor beta-1 (TGF-beta1) gene and cooperation with Sp1, Jun-B, p21WAF1/Cip1, and stimulates apoptosis by transactivation of the p53 gene.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::d1aa9919798f3aff6354ff4cc726bfd8 https://pubmed.ncbi.nlm.nih.gov/9476963 Zobrazit plný text záznamu