The gene for the serpin thrombin inhibitor (PI7), protease nexin I, is located on human chromosome 2q33-q35 and on syntenic regions in the mouse and sheep genomes

Autor:	R E, Carter, K M, Cerosaletti, D J, Burkin, R E, Fournier, C, Jones, B D, Greenberg, B A, Citron, B W, Festoff
Rok vydání:	1995
Předmět:	Sheep Chromosome Mapping Receptors Cell Surface Hybrid Cells Rats Protease Nexins Amyloid beta-Protein Precursor Mice Liver Neoplasms Experimental Genes Species Specificity Chromosomes Human Pair 2 Cricetinae Tumor Cells Cultured Animals Humans Carrier Proteins Serpins
Zdroj:	Genomics. 27(1)
ISSN:	0888-7543
Popis:	Protease nexin I (PNI) is the most important physiologic regulator of alpha-thrombin in tissues. PNI is highly expressed and developmentally regulated in the nervous system where it is concentrated at neuromuscular junctions and also central synapses in the hippocampus and striatum. Approximately 10% of identified proteins at mammalian neuromuscular junctions are serine protease inhibitors, consistent with their central role in balancing serine protease activity to develop, maintain, and remodel synapses. Southern blot hybridization of PNI cDNA to somatic cell hybrids placed the structural gene for PNI (locus PI7) on human chromosome 2q33-q35 and to syntenic chromosomes in the mouse (chromosome 1) and sheep (chromosome 2).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::d12d49576cd32d624853e002ddcd4afd https://pubmed.ncbi.nlm.nih.gov/7665170 Zobrazit plný text záznamu Full Text from ScienceDirect