Synthesis and pH-responsive dissociation of framboidal ABC triblock copolymer vesicles in aqueous solution† †Electronic supplementary information (ESI) available: Full experimental details for the synthesis and characterisation of the diblock and triblock copolymer vesicles, assigned 1H NMR spectra, GPC traces, digital images of dispersions, additional plots of pH vs. hydrodynamic diameter, count rate and zeta potential, a table of SAXS parameters, extra data for G58H250D184 and un-merged SAXS patterns are provided. See DOI: 10.1039/c7sc04788f
| Autor: | Mable, C. J., Fielding, L. A., Derry, M. J., Mykhaylyk, O. O., Chambon, P., Armes, S. P. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Chemical Science |
| ISSN: | 2041-6539 2041-6520 |
| Popis: | A series of framboidal ABC triblock copolymer vesicles were prepared from precursor diblock copolymer vesicles via RAFT seeded emulsion polymerisation and their acid-induced dissociation was characterised by SAXS. A series of pH-responsive all-methacrylic ABC triblock copolymer vesicles were prepared from precursor diblock copolymer vesicles via RAFT seeded emulsion polymerisation. Microphase separation between the two hydrophobic membrane-forming B and C blocks produced a distinctive framboidal morphology, for which the mean globule size can be tuned by adjusting the triblock copolymer composition. These vesicles remain intact at neutral pH, but undergo irreversible dissociation on addition of acid as a result of protonation of the tertiary amine groups located within the third block. Small-angle X-ray scattering (SAXS) was utilised to characterise the morphologies formed at pH 8 and pH 3. According to time-resolved SAXS studies, the acid-induced dissociation of these pH-responsive framboidal vesicles involves appreciable membrane swelling within 50 ms and is complete. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|