[Analysis of therapeutic effect and prognosis in patients with metastatic colorectal cancer and different K-ras status]
| Autor: | Fei-jiao, Ge, Jian-zhi, Liu, Shan-shan, Li, Yan, Wang, Lie-jun, Liu, Kai, Yao, Chuan-hua, Zhao, Ya-Li, Fu, Li, Lin, Jian-ming, Xu |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Lung Neoplasms Organoplatinum Compounds Liver Neoplasms Antibodies Monoclonal Antineoplastic Agents Middle Aged Irinotecan Antineoplastic Agents Phytogenic Combined Modality Therapy Disease-Free Survival ErbB Receptors Oxaliplatin Survival Rate Genes ras Mutation Humans Camptothecin Female Colorectal Neoplasms Aged Follow-Up Studies Retrospective Studies |
| Zdroj: | Zhonghua zhong liu za zhi [Chinese journal of oncology]. 35(4) |
| ISSN: | 0253-3766 |
| Popis: | To evaluate the correlation of clinical effect and prognosis between patients with metastatic colorectal cancer (mCRC) and different K-ras status.The clinical characteristics, chemotherapeutic regimens and survival of 153 mCRC patients with different K-ras status were analyzed retrospectively.The median overall survival (OS) in patients without K-ras mutation were 31.7 months, significantly longer than 21.3 months in the patients with K-ras mutation (P = 0.037). The median progression-free survival (PFS) and OS in patients who received chemotherapy followed by anti-EGFR antibody treatment were 11.5 and 39.3 months, respectively, significantly longer as compared with the PFS and OS in those received chemotherapy in combination with anti-EGFR antibody concomitantly (5.7, P = 0.02, and 28.7 months, P = 0.034, respectively).K-ras status is a prognostic biomarker for mCRC patients treated with anti-EGFR antibody. The combination settings of anti-EGFR in combination with chemotherapy may improve survival of mCRC patients with wild-type K-ras status. |
| Databáze: | OpenAIRE |
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