Chlorpyrifos alters expression of enzymes involved in vitamin D

Autor:	Krzysztof, Sawicki, Magdalena, Czajka, Magdalena, Matysiak-Kucharek, Jacek, Kurzepa, Paulina, Wojtyła-Buciora, Karol, Zygo, Marcin, Kruszewski, Lucyna, Kapka-Skrzypczak
Rok vydání:	2020
Předmět:	25-Hydroxyvitamin D3 1-alpha-Hydroxylase Chlorpyrifos Vitamin D Vitamin D3 24-Hydroxylase Cholecalciferol Skin
Zdroj:	Pesticide biochemistry and physiology. 174
ISSN:	1095-9939
Popis:	Skin acts as a mechanical barrier between human body and environment. Epidermal cells are regularly exposed to many physiological and environmental stressors, such as pesticides, like chlorpyrifos (CPS). It is recognised that CPS may affect metabolism of other exo- and endogenous substances by affecting enzyme activity and expression. This study aims to investigate the effect of CPS on expression of CYP27A1, CYP27B1 and CYP24A1, the enzymes involved in synthesis and metabolism of vitamin D
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::cf171560e0ea24a65495122f44e50cee https://pubmed.ncbi.nlm.nih.gov/33838712 Zobrazit plný text záznamu Full Text from ScienceDirect