Expression of p21 and p27 in gallbladder cancer
| Autor: | Fawzi M, Alsheyab, Moroug T, Ziadeh, Kamal E, Bani-Hani |
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| Rok vydání: | 2007 |
| Předmět: | |
| Zdroj: | Saudi medical journal. 28(5) |
| ISSN: | 0379-5284 1994-2001 |
| Popis: | To investigate the expression of p21 and p27 factors in gallbladder cancer (GBC), and to correlate their expression with clinicopathological parameters: age, gender, stage, invasion, and grade.Thirty-two surgically resected specimens were collected between 1994-2001 from different health centers in north Jordan. Tissues belong to 25 females and 7 males were examined immunohistochemically. The study took place in the Pathology Department, Jordan University of Science and Technology, Jordan.Levels of p21 were found in 75% and p27 in 25%. Furthermore, p21 was expressed in 50% of the specimens which are belong to patients with ages64 years, whereas all specimens for ages64 years have p21WAF1/CIP1 expression (p=0.001). The expression of p21 between advanced stages (stages III and IV) was 89.5% and early stages (stages I and II) was 53.8 % (p=0.031).The p27 expression was markedly decreased in GBC cases (25%) and there were no significant correlation between p27KIP1 expression and all clinicopathological parameters including gender, World Health Organization grades, stages, and invasion, whereas the expression of p21 was 75% and there was a significant correlation between p21 and the clinicopathological parameters including gender, stages, and invasion. |
| Databáze: | OpenAIRE |
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