Immunoexpression of Transforming Growth Factor Beta 3 (TGFβ3) and Its Receptor Type III (TGFβRIII) in Basal Cell Carcinomas

Autor:	FLORESCU, D., STEPAN, A.E., MĂRGĂRITESCU, C., SIMIONESCU, C.E., STEPAN, D.
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Original Paper transforming growth factor basal cell carcinoma
Zdroj:	Current Health Sciences Journal
ISSN:	2069-4032 2067-0656
Popis:	Basal cell carcinomas (BCCs) are malignant tumors with particular biological prognosis and behavior, and the biomolecular investigation of these lesions can provide important therapeutic targets for epithelial neoplasia. In this study we analyzed the immunoexpression of transforming growth factor beta 3 (TGFβ3) and its receptor type III (TGFβRIII) for 53 cases of BCC in relation to the main histopathological prognostic parameters. The results indicated statistically significant differences of TGFβ3 and TGFβRIII expression related to histological type and lesion stage, the both proteins being higher expressed in adenoid and morpheaform advanced stage tumors. In this study, TGFβ3 and TGFβRIII immunoexpression analysis indicated their utility for identifying aggressive BCCs with potential for tumor progression
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::ce01d79cb1dcb1f54c3bd8f6232423d4 http://europepmc.org/articles/PMC6320465 Zobrazit plný text záznamu Plný text ve formátu PDF