Biological activity and apoptotic signaling pathway of C

Autor:	Mansour M, Nawasreh, Elham I, Alzyoud, Zainab A, Al-Mazaydeh, Majdoleen S, Rammaha, Salem R, Yasin, Lubna H, Tahtamouni
Rok vydání:	2019
Předmět:	MCF-7 Cells Molecular Conformation Tumor Cells Cultured Humans Phenazines Antineoplastic Agents Apoptosis Spiro Compounds Steroids Drug Screening Assays Antitumor K562 Cells Cell Proliferation Signal Transduction
Zdroj:	Steroids. 158
ISSN:	1878-5867
Popis:	Cephalostatin 1, a potent anti-cancer agent, is a natural bis-steroidal alkaloid that causes cell death in the subnanomolar to picomolar ranges via an atypical apoptosis pathway. Although cephalostatin 1 is a highly effective anticancer drug, its availability limits its utilization. We previously reported the synthesis of two 12'α-hydroxy derivatives of cephalostatin 1 that induce cell death by activating the ER stress apoptosis signaling pathway. For the current work, we synthesized six C
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::cd1488aec55ec20ef6cf82cad040dfcb https://pubmed.ncbi.nlm.nih.gov/32092307 Zobrazit plný text záznamu Full Text from ScienceDirect