| Autor: |
V G, Galaktionov, T V, Anfalova, L N, Semenkova, E I, Dudich |
| Rok vydání: |
1991 |
| Předmět: |
|
| Zdroj: |
Zhurnal obshchei biologii. 52(4) |
| ISSN: |
0044-4596 |
| Popis: |
Cellular, humoral, and genetic mechanisms of induction of T-effectors of the transplant vs. host reaction (THR) have been studied in two-cell culture of phagocyte mononuclears and thymocytes. A direct physical contact and similarity of H-2K locus of major histocompatibility complex between the cooperating cells in culture is required for successful induction of T-effectors of THR. Contact interaction of macrophages with thymocytes leads to accumulation of a 67 KDa humoral factor in the culture medium. Incubation of intact thymocytes with this factor leads to functional transformation of immature thymocytes into corresponding effector cells. Similarity of H-2K locus of the factor producers and intact lymphocytes is also required for successful humoral induction of the T-effectors. The surface H-2K antigen is able to induce formation of THR t-effectors from non-reactive thymocytes. The H2-K-specific mediator, affinity-isolated from the supernatant of the macrophage-thymocyte culture can also cause this induction. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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