Tumour cell-activated platelets modulate the immunological activity of CD4

Autor:	Lukas M, Gockel, Katrin, Nekipelov, Vito, Ferro, Gerd, Bendas, Martin, Schlesinger
Rok vydání:	2021
Předmět:	CD4-Positive T-Lymphocytes Killer Cells Natural Heparin CD8-Positive T-Lymphocytes Heparin Low-Molecular-Weight
Zdroj:	Cancer immunology, immunotherapy : CII. 71(10)
ISSN:	1432-0851
Popis:	Platelets, key players in haemostasis, are progressively investigated with respect to their role in immunity and inflammation. Although the platelet support to haematogenous cancer cell metastasis has been the subject of multiple studies, their impact on anti-cancer immunity remains unaddressed. Here, we investigated the immunomodulatory potential of platelets upon their activation by MDA-MB-231 breast cancer cells in various in vitro approaches. We provide evidence that platelets as well as their tumour cell-induced releasates increased the ratio of regulatory T cells, shaping an immunosuppressive phenotype in isolated CD4
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::cb486aa80ef99b0bd0b1259b34475e47 https://pubmed.ncbi.nlm.nih.gov/35285006 Zobrazit plný text záznamu Full text from SpringerLink