Simultaneous Improvement of Limonene Production and Tolerance in

Autor: Jian, Li, Kun, Zhu, Lin, Miao, Lanxin, Rong, Yu, Zhao, Shenglong, Li, Lijuan, Ma, Jianxun, Li, Cuiying, Zhang, Dongguang, Xiao, Jee Loon, Foo, Aiqun, Yu
Rok vydání: 2021
Předmět:
Zdroj: ACS synthetic biology. 10(4)
ISSN: 2161-5063
Popis: Limonene is an important plant natural product widely used in food and cosmetics production as well as in the pharmaceutical and chemical industries. However, low efficiency of plant extraction and high energy consumption in chemical synthesis limit the sustainability of industrial limonene production. Recently, the advancement of metabolic engineering and synthetic biology has facilitated the engineering of microbes into microbial cell factories for producing limonene. However, the deleterious effects on cellular activity by the toxicity of limonene is the major obstacle in achieving high-titer production of limonene in engineered microbes. In this study, by using transcriptomics, we identified 82 genes from the nonconventional yeast
Databáze: OpenAIRE